A biopsy is the “gold standard” for diagnosis. Imaging like X-rays can show a tumor exists, but only a biopsy can tell the doctors exactly what it is.
The Procedure: For bone cancer, doctors typically use a Core Needle Biopsy. Under local or general anesthesia, a hollow needle is used to take a small “core” of tissue from the tumor.
The Pathology Check: These tissue samples are sent to a Pathologist, who examines the cells under a microscope to look for the specific markers of Osteosarcoma or Ewing Sarcoma.
Surgical Precision: In bone cancer, the “path” the needle takes is very important. The biopsy is usually performed by the same Surgical Oncologist who will eventually remove the tumor, ensuring the needle track can be safely removed during later surgery.

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Source: MD Anderson – Bone Cancer Diagnosis
Disclaimer: The Cyrus Desai Charitable Foundation provides this information for educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your oncologist or other qualified health provider with any questions you may have regarding a medical condition.
